Conditional independence tests have received special attention lately in machine learning and computational intelligence related literature as an important indicator of the relationship among the variables used by their models. In the field of probabilistic graphical models, which includes Bayesian network models, conditional independence tests are especially important for the task of learning the probabilistic graphical model structure from data. In this paper, we propose the full Bayesian significance test for tests of conditional independence for discrete datasets. The full Bayesian (...) significance test is a powerful Bayesian test for precise hypothesis, as an alternative to the frequentist’s significance tests (characterized by the calculation of the p-value). (shrink)

Este nuevo libro colectivo recoge los trabajos del grupo de investigación de Filosofía de la PUCE, elaborados entre 2019 y 2020. El tema elegido, Tecnología y política, define una de las problemáticas contemporáneas más relevantes dentro del trabajo académico. Como en ocasiones anteriores, cada autor plantea contextos de lectura diversos; los aportes recorren un escenario complejo, resultado de los caminos que cada uno ha elegido para consolidar su propia reflexión a partir de los proyectos de escritura de tesis de posgrado (...) y de investigaciones desarrolladas tanto en universidades europeas como americanas. Sin embargo, el punto de encuentro está dado en la perspectiva y en las condiciones que determinan la posibilidad de proponer un pensamiento crítico y propositivo desde América Latina. (shrink)

Estudio sobre el contexto filosófico de la Escuela de Madrid, y sus inicios, a colación de la figura de Juan Rof Carballo.

El presente estudio tiene como propósito presentar a un pensador que murió hace apenas doce años, y que por varios motivos pudiera considerarse un “hereje” para la ortodoxia que dictan las corrientes filosóficas en boga hoy. No se trata, todavía, de un filósofo reconocido ampliamente, ni de uno muy popular: su discurso es profundo y a veces resulta arduo de leer. Sin embargo —es la opinión que se mantiene aquí— su pensamiento es sumamente valioso. Va directamente al núcleo de los (...) problemas más intrincados de la filosofía actual, y, sobre todo en el ámbito de la metafísica, aporta vías de solución que merecen un atento análisis. El tema del amor no queda exento. Su situación en los campos ético y antropológico llega a la total confusión o, peor, al sinsentido y la cosificación. Y el fondo del problema es —eso creemos aquí— de índole metafísica. Por eso se emprende una descripción del pensamiento de Cardona al respecto, en tres momentos: primero, la fundamentación del amor en el acto de ser, segundo en la explicación de toda la realidad a través del amor, y su importancia como sentido del hombre. Como conclusión se ofrece una sucinta valoración del aporte de Cardona al tema. (shrink)

El psicoanálisis surgió, hacia fines del siglo XIX, como una teoría científica que pretende explicar el aparato psíquico y como una forma de psicoterapia que es una aplicación de ella. Desde entonces, su metapsicología y sus técnicas de intervención han cambiado mucho, sobre todo como consecuencia del contraste permanente con la evidencia clínica. En muchos casos, sin embargo, su epistemología y su filosofía de la mente siguen siendo deudoras de los presupuestos teóricos con los que nació. Eso es doblemente negativo. (...) Por una parte, porque esa epistemología decimonónica suele estar comprometida con formas de fisicalismo y reductivismo que son por lo menos discutibles y que tienen consecuencias respecto de su concepción de lo mental. De otro lado, porque no facilita su integración con la filosofía de la mente actual. En este texto me propongo reseñar y comentar algunas tesis del libro de Carlos Caorsi, con el objetivo de mostrar la necesidad de mayor diálogo entre psicoanálisis y filosofía de la mente, concentrándome sobre todo en la ontología de lo mental que pudo haber presupuesto Freud y en la tesis de Caorsi sobre los sistemas lógicos que subyacerían a los sistemas psíquicos de la primera tópica freudiana. (shrink)

Replies to commentators Respuestas a los comentarios críticos de Carlos Patarroyo, Mirja Pérez de Calleja y Pablo Rychter.

From the back cover: "Un repaso de las publicaciones que han abordado las relaciones e intercambios entre los Estados Unidos de América y España, arroja un saldo positivo en los ámbitos sociológico, político y cultural; no así en el estricto campo de la filosofía, necesitado todavía de mayores estudios. Los once trabajos que integran Estados Unidos/España: Diálogos filosóficosrepresentan un esmerado aporte en esta dirección: el de paliar el citado desequilibrio mediante la reflexión en torno al influjo del pensamiento estadounidense en (...) España y a la recepción de la filosofía española —a través de Unamuno, Ortega y Gasset y Julián Marías— en la patria de Walt Whitman.“Es muy deseable que este activo diálogo filosófico entre los Estados Unidos y España se desarrolle todavía más en los próximos años” (cit. Jaime Nubiola). Esta ha sido la principal aspiración de esta obra: ensanchar este intercambio, esclarecer sus múltiples direcciones y abrir nuevos caminos de investigación.". (shrink)

Benchmarking automated theorem proving (ATP) systems using standardized problem sets is a well-established method for measuring their performance. However, the availability of such libraries for non-classical logics is very limited. In this work we propose a library for benchmarking Girard's (propositional) intuitionistic linear logic. For a quick bootstrapping of the collection of problems, and for discussing the selection of relevant problems and understanding their meaning as linear logic theorems, we use translations of the collection of Kleene's intuitionistic theorems in the (...) traditional monograph "Introduction to Metamathematics". We analyze four different translations of intuitionistic logic into linear logic and compare their proofs using a linear logic based prover with focusing. In order to enhance the set of problems in our library, we apply the three provability-preserving translations to the propositional benchmarks in the ILTP Library. Finally, we generate a comprehensive set of reachability problems for Petri nets and encode such problems as linear logic sequents, thus enlarging our collection of problems. (shrink)

The 20th Century is the starting point for the most ambitious attempts to extrapolate human life into artificial systems. Norbert Wiener’s Cybernetics, Claude Shannon’s Information Theory, John von Neumann’s Cellular Automata, Universal Constructor to the Turing Test, Artificial Intelligence to Maturana and Varela’s Autopoietic Organization, all shared the goal of understanding in what sense humans resemble a machine. This scientific and technological movement has embraced all disciplines without exceptions, not only mathematics and physics but also biology, sociology, psychology, economics etc. (...) New terms were developed, such as “information”, “organization”, “entropy”, “communication”, “encryption”, “computation” and “algorithmics” to mention a few, all which had an enormous impact on artificial systems. Our work follows this historical track but with a reversed order of priorities. Instead of deducing a reduced group of human acts into an artificial environment, we deduce the human aspects of machines by extrapolating algorithmic methodologies into everyday life acts. The present informational theories were insufficiently powered to achieve this objective without developing a new theoretical approach. Hence, our research is directed towards an expansion of the current informational theories. (shrink)

This book is the result of a collective research effort performed during many years in both Sweden and Spain. It is the result of attempting to develop a new field of research that could we denominate «human act informatics.» The goal has been to use the technologies of information to the study of the human act in general, including embodied acts and disembodied acts. The book presents a theory of the quantification of the informational value of human acts as order, (...) opposing the living order against entropy. We present acting as a set of decisions and choices aimed to create order and to impose Modernity. Karl Popper’s frequency theory of probability is applied to characterize human acts regarding their degree of freedom and to set up a scale of order in human decisions. The traditional theory of economics and social science characterize the human act as rational, utilitarian and ethical. Our results emphasize that the unique significance of an act lies in its capacity to generate order. An adequate methodology is then presented to defend such hypothesis according to which, the rationality respective irrationality of acting, is in fact only a function of the act’s organizational capacity. From this perspective, it has been necessary to define «order» respective «disorder» as operative concepts that allowed the comparison of the organizational differences generated by each kind of act. According to the presented conclusions, the spontaneity of living, as unconscious thinking, dreaming, loving, etc. and the mainstream of the human acts, are utilitarian, but in an irrational way; they are rooted in unconscious drifts and therefore must be considered irrational-utility acts. (shrink)

Integrated Information Theory (IIT) is one of the most influential theories of consciousness, mainly due to its claim of mathematically formalizing consciousness in a measurable way. However, the theory, as it is formulated, does not account for contextual observations that are crucial for understanding consciousness. Here we put forth three possible difficulties for its current version, which could be interpreted as a trilemma. Either consciousness is contextual or not. If contextual, either IIT needs revisions to its axioms to include contextuality, (...) or it is inconsistent. If consciousness is not contextual, then IIT faces an empirical challenge. Therefore, we argue that IIT in its current version is inadequate. (shrink)

La multiplicación de las dimensiones de la realidad acarrea consigo una serie de posibilidades que han permitido reproducir dinámicas humanas del mundo físico en ámbitos no contemplados con anterioridad. La realidad virtual se configura como el nivel de más significación actual para replantearse lo que es el ser humano, lo cual hace que esta funja como una potencialidad ontológica sin parangón. Sin embargo, su amplitud trae consigo una amplia serie de dificultades, que cuestionan las bases ontológicas de la constitución del (...) ser humano y la manera cómo sea dado a lo largo de la historia la interacción entre los individuos. Estas potencialidades recrean amenazas que patentizan la fragilidad del sujeto. Es por ello necesario reflexionar sobre estas dificultades, analizando las características que la virtualidad recrea y cómo funciona en la construcción de la identidad personal y la autoconcepción del individuo. Aceptar que lo virtual constituye también una dimensión de la realidad humana que extiende sus características y que influye severamente en la transformación de su ontología permitirá descubrir nuevos caminos de reflexión y análisis que alejen las amenazas que buscan socavar lo humano y, ante su fragilidad, se presenten como herramientas para continuar trabajando en la igualdad y la dignidad de cada individuo. (shrink)

En los estudios sobre la desobediencia civil el uso de la violencia como recurso de protesta ha sido uno de los problemas irresueltos. En parte, ello se debe a la falta de criterios ético-políticos que delimiten el entendimiento propio de la violencia. El presente artículo ofrece una ruta de comprensión de la violencia de tal modo que sea circunscrita en la discusión sobre la participación de la ciudadanía disidente en contextos democráticos. Se revisan las contribuciones de la literatura clásica y (...) contemporánea; y, finalmente, se estriba en el principio de dignidad humana como condicionante de la civilidad de los actos contestatarios. (shrink)

Mediante una investigación teórica y de trabajo de campo en relación a la adaptación de la titulación de arquitectura al EEES y con el objetivo de hacer efectivo un despliegue gradual del desarrollo de las competencias del submódulo de dibujo, se exponen los resultados de la coordinación entre asignaturas y una selección crítica y comparativa de actividades de aprendizaje. Se indaga además en la dispar distribución de las materias de dibujo de la adaptación al plan de bolonia, concluyendo con una (...) propuesta de despliegue independiente y mejorada del submódulo desvinculado de las materias que no le son afines. (shrink)

Cualquiera que sea la opinión que uno tenga sobre la participación de la Iglesia católica en los debates políticos del Ecuador, nadie negará que ha sido y sigue siendo un actor importante de estos debates. Conocer sus ideas políticas contribuye a entender mejor este rol y a juzgarlo con más fundamento y menos apasionamiento. Por esto, el actual volumen reúne textos selectos de cinco pensadores católicos ecuatorianos representativos, desde fines del siglo XIX hasta las últimas décadas del siglo XX. Hablamos (...) de: • Monseñor Federico González Suárez (1844 – 1917). Historiador, arqueólogo, Obispo de Ibarra (1895 – 1905) y Arzobispo de Quito (1906 – 1917). • Cardenal Carlos María de la Torre (1873 – 1968). Arzobispo de Quito (1933-1967) y Cardenal desde 1953. • Julio Tobar Donoso (1894 – 1981). Jurista, diplomático, historiador. • Cardenal Pablo Muñoz Vega (1903 – 1994). Arzobispo de Quito (1967- 1985) y Cardenal desde 1969. • Monseñor Leonidas Proaño (1910 – 1988). Obispo de Riobamba (1954-1985) y candidato al Premio Nobel de la Paz en 1986. El objetivo de esta publicación es ofrecer una síntesis coherente del pensamiento político de estos autores, a pesar de las diferencias que entre ellos existen. No ofrecemos una compilación sobre “el” pensamiento político católico, así dicho en general, porque sería exhaustivo y pretencioso. Nos limitaremos a presentar una síntesis que nos introduzca a las principales cuestiones sociales y políticas que han preocupado a estas cinco figuras. Este trabajo tiene naturalmente sus límites debidos al amplio espacio de tiempo considerado, las múltiples cuestiones políticas implicadas y la productividad de los autores, todos ellos pensadores a la vez que personas de acción. (shrink)

Estamos siendo testigos de grandes avances tecnológicos y, a la vez, de grandes desastres naturales y sociales que nos impulsan a plantearnos cuáles son las causas últimas de la degradación natural ecológica. El abuso en el uso de los recursos tal vez pueda tener relación con el abuso en el uso de la tecnología; incluso ser causa de la gran desigualdad social en el acceso a bienes necesarios para llevar una vida digna, raíz de muchos conflictos sociales. La ecología es (...) una disciplina científica, pero cada vez es más habitual ampararse en este término para lanzar opiniones o generar un debate de ideologías de índole catastrofista que no hacen más que generar malestar social sin visos de solución práctica. Las reflexiones sobre la ecología nos parece que deben plantearse de una forma interdisciplinar, pero no de cualquier manera, sino respetando el estatuto epistemológico de cada área del saber. Cuidar el método científico, en el ámbito científico; el filosófico, en el suyo propio; e incluso el teológico. El tema de nuestra relación con la naturaleza nos afecta tan íntimamente que casi todas las áreas del conocimiento pueden decir algo al respecto. En el presente trabajo comenzamos ese diálogo y presentamos las ideas básicas desde las que se podría plantear un modo de actuar humano respetuoso para con los demás hombres y los demás seres de la naturaleza, que mejore nuestro modo de vivir y evite más daños y perjuicios. A esto nos referimos cuando hablamos de “ética ambiental”. La ecología nos toca de cerca porque tiene que ver con el modo de habitar nuestro mundo y las relaciones que tenemos con los demás seres vivos y no vivos. A fin de poder delinear las líneas principales de una ética orientada al medioambiente es preciso, en primer lugar, conocer los datos científicos sobre el tema; en segundo lugar, analizar los problemas graves que se están detectando y comprender que muchas de sus causas todavía son desconocidas y precisan de un estudio más detenido; finalmente, es conveniente revisar las alternativas de solución que nos orienten a llevar una vida mejor, donde se sugieran modos de obrar que no nos cierren el camino hacia ese destino común que tenemos como seres humanos, y que integre al resto de criaturas porque no somos los únicos seres vivientes del planeta. La propuesta de una “ética ambiental” apunta a considerar un verdadero “ecologismo solidario”. (shrink)

Preface to the thematic volume Metatheoretical Structuralism: Some Recent Developments and Applications.

El presente escrito tiene por objetivo exponer la fundamentación de la visibilidad del poder a partir del principio de publicidad kantiano, esgrimido en sus textos de filosofía política, y de la crítica al poder invisible empuñada por Norberto Bobbio. Teniendo presente que Kant no se afirma como un defensor de la democracia, es gracias al rediseño bobbiano del principio de publicidad que puede colocarse procedimentalmente como base de la transparencia de la toma de decisiones tan propia de la democracia.

It is not yet clear which response behavior requires self-regulatory effort in the moral dilemma task. Previous research has proposed that utilitarian responses require cognitive control, but subsequent studies have found inconsistencies with the empirical predictions of that hypothesis. In this paper we treat participants’ sensitivity to utilitarian gradients as a measure of performance. We confronted participants (N = 82) with a set of five dilemmas evoking a gradient of mean utilitarian responses in a 4-point scale and collected data on (...) heart rate variability and on utilitarian responses. We found positive correlations between tonic and phasic HRV and sensitivity to the utilitarian gradient in the high tonic group, but not in the low tonic group. Moreover, the low tonic group misplaced a scenario with a selfish incentive at the high end of the gradient. Results suggest that performance is represented by sensitivity correlated with HRV and accompanied with a reasonable placement of individual scenarios within the gradient. (shrink)

We describe a software system for the analysis of defined benefit actuarial plans. The system uses a recursive formulation of the actuarial stochastic processes to implement precise and efficient computations of individual and group cash flows.

Statistical tests that detect and measure deviation from the Hardy-Weinberg equilibrium (HWE) have been devised but are limited when testing for deviation at multiallelic DNA loci is attempted. Here we present the full Bayesian significance test (FBST) for the HWE. This test depends neither on asymptotic results nor on the number of possible alleles for the particular locus being evaluated. The FBST is based on the computation of an evidence index in favor of the HWE hypothesis. A great deal of (...) forensic inference based on DNA evidence assumes that the HWE is valid for the genetic loci being used. We applied the FBST to genotypes obtained at several multiallelic short tandem repeat loci during routine parentage testing; the locus Penta E exemplifies those clearly in HWE while others such as D10S1214 and D19S253 do not appear to show this. (shrink)

A number of experiences have demonstrated how digital solutions are effective in improving quality of life (QoL) and health outcomes for older adults. Smart Health Age-Friendly Environments (SHAFE) is a new concept introduced in Europe since 2017 that combines the concept of Age-Friendly Environments with Information Technologies, supported by health and community care to improve the health and disease management of older adults and during the life-course. This chapter aims to provide an initial overview of the experiences available not only (...) in Europe, based on the research work of the participants of the International Interdisciplinary Network on Health and Well-being in an Age-Friendly Digital World (NET4Age-Friendly), which could be of interest to preventive, health and social authorities. The chapter reports good practices, pain points, and bottlenecks that may require a collaborative, interdisciplinary research approach to facilitate the transformations towards smart, sustainable, health and age-friendly cities and communities. (shrink)

Abordagens pós-cognitivistas mais recentes têm lançado duras críticas à noção de representação mental, procurando ao invés disso pensar a mente e a cognição em termos de ações corporificadas do organismo em seu meio. Embora concordemos com essa concepção, não está claro que ela implique necessariamente a rejeição de qualquer tipo de vocabulário representacional. O objetivo deste artigo é argumentar que representações podem nos comprar uma dimensão explicativa adicional não disponível por outros meios e sugerir que, ao menos em alguns casos, (...) elas podem participar da explicação de performances ou capacidades cognitivas. A noção de representação apresentada, como deixaremos claro ao longo do artigo, não viola os preceitos metodológicos mais caros à cognição 4E em geral e ao enativismo em particular, podendo, portanto, ser utilizada como uma ferramenta teórica útil em investigações sobre a natureza corporificada e situada da mente. (shrink)

Este escrito tiene por objetivo destacar el papel de la performatividad del discurso en la desobediencia civil. Asimismo, se pretende esclarecer el lugar que ocupa la desobediencia civil en las democracias contemporáneas. Como se desea argumentar, la desobediencia civil lejos de negar el estado de derecho reivindica los fundamentos constitucionales y es capaz de someter a duda leyes y normas injustas. Este ejercicio reflexivo toma como punto de inicio la teoría contractualista como fundamentación moderna de la obediencia del Estado de (...) derecho, para posteriormente asentar una mirada contemporánea, de la mano de las actualizaciones de la teoría hechas por autores como Hannah Arendt, John Rawls y Jürgen Habermas. (shrink)

To manage conflicts between temptation and commitment, people use self-control. The process model of self-control outlines different strategies for managing the onset and experience of temptation. However, little is known about the decision-making factors underlying strategy selection. Across three experiments (N = 317), we tested whether the moral valence of a commitment predicts how people advise attentional self-control strategies. In Experiments 1 and 2, people rated attentional focus strategies as significantly more effective for people tempted to break moral relative to (...) immoral commitments, even when controlling for perceived temptation and trait self-control. Experiment 3 showed that as people perceived commitments to have more positive moral valence, they judged attentional focus strategies to be significantly more effective relative to attentional distraction strategies. Moreover, this effect was partly mediated by perceived differences in motivation. These results indicate that moralization informs decision-making processes related to self-control strategy selection. (shrink)

En 1968 Raquel Carson comenzaba una revolución en el pensamiento, quizá una de las de mayor peso en la actualidad. En su libro "La primavera silenciosa" acusaba del deterioro ambiental al poder ilimitado del ser humano. La creencia surgida en la modernidad de que todo lo que el hombre decidía era en sí mismo lo mejor por haber sido fruto de una voluntad libérrima, daba primacía y legitimidad absoluta a su acción sobre la naturaleza. Surgieron con gran fuerza numerosos grupos (...) ecologistas que adoptaron un pensamiento que responde al nombre de "ecología profunda" o "Deep Ecology" descrito por primera vez por Arme Naess en un artículo publicado por la revista Inquiry y titulado "The Shallow and the Deep, Long Range Ecology Movement". Los principios que proponía este movimiento (Naess 1984) pueden ser resumidos en ocho grandes puntos: 1) la vida de los seres no humanos es un valor en sí: 2) la riqueza y la diversidad de estas formas de vida son también valores en sí; 3) los seres humanos no pueden intervenir de manera destructiva en la vida; 4) a este respecto, la intervención humana actual es eminentemente excesiva; 5) por consiguiente, las reglas de juego deben ser radicalmente modificadas; 6) esta modificación radical debe hacerse tanto a nivel de las estructuras económicas como de las estructuras ideológicas y culturales; 7) a nivel ideológico, el cambio principal consiste en apreciar más la calidad de la vida que el goce de los bienes materiales; 8) las personas que acepten estos principios tienen la obligación de contribuir, directa o indirectamente a la realización de los cambios fundamentales que aquellos implican. (shrink)

in Oct-14-1998 ordinance INDESP-IO4 established the federal software certification and verification requirements for gaming machines in Brazil. The authors present the rationale behind these criteria, whose basic principles can find applications in several other software authentication applications.

We show how the Full Bayesian Significance Test (FBST) can be used as a model selection criterion. The FBST was presented by Pereira and Stern as a coherent Bayesian significance test. Key Words: Bayesian test; Evidence; Global optimization; Information; Model selection; Numerical integration; Posterior density; Precise hypothesis; Regularization. AMS: 62A15; 62F15; 62H15.

This article presents important properties of standard discrete distributions and its conjugate densities. The Bernoulli and Poisson processes are described as generators of such discrete models. A characterization of distributions by mixtures is also introduced. This article adopts a novel singular notation and representation. Singular representations are unusual in statistical texts. Nevertheless, the singular notation makes it simpler to extend and generalize theoretical results and greatly facilitates numerical and computational implementation.

This is a study of sophía from the passage 20d-21a in Plato’s Apology. There, Socrates tries to understand what kind of wisdom he would have, since the Oracle of Delphi stated that no one would be wiser than him. An investigation of historical aspects was made to understand the trial of Socrates and conviction, also a mapping of sophía’s main uses through the corpus platonicum was built, as well an overview of the usage of this concept by others greek authors. (...) In addition, a side of the figure of Socrates that has been given little attention was perceived, becoming important to explain the influence of magical thinking on his philosophy and his relationship with shamanism. Este é um estudo sobre sophía que parte da passagem 20d-21a na Apologia de Platão. Ali, Sócrates tenta compreender que tipo de sabedoria ele teria, uma vez que o Oráculo de Delfos afirmou que ninguém seria mais sábio que ele. Para discutir isso, foi feito um estudo sobre os aspectos históricos que se relacionam com o julgamento e a condenação de Sócrates, um mapeamento dos principais usos de sophía por todo o corpus platonicum, bem como uma análise do panorama relacionado ao uso desse conceito por outros autores do mundo grego. Além disso, foi percebido um lado pouco comentado da figura de Sócrates, tornando-se importante explanar sobre a influência do pensamento mágico em sua filosofia e a7 relação dele com o xamanismo. (shrink)

Initially, in this article, we present the foundation on which current science stands. Next, we explain the main stream of modern science, the “Popperian Falsificationism”, and show why the current criticism to the system is flawed. Later, we will prove that the “falsificationism” is logically inconsistent and we will propose a new concept of science, unifying it with philosophy.

El presente artículo analiza los principales argumentos de la reacción comunitarista frente al liberalismo, debido a su enfoque individualista y su defensa del modelo contractual. Se destaca la presencia de una triple raíz que se hunde hasta la filosofía política de Aristóteles, Hegel y Marx. Finalmente, se analizarán los l ́ımites dela frontera entre ambas comprensiones de la política, as ́ı como los riesgos en que incurren las democracias modernas al omitir la presencia del libertarismo como ideología depositaria de principios (...) tanto liberales como comunitaristas. (shrink)

The complex world of thought and sensitivity in the sphere of contemporary art has entailed the revision and exclusion of disciplines aimed at providing a model to explain and conceptualize reality. Art history, as one such discipline, has had many of its contributions questioned from Gombrich’s epistemological reformulation to the postmodern discourses, which extol the death of the author, the post-structuralist idea of tradition as a textual phenomenon, and the declaration of the death of history as a consequence of the (...) hybridization of disciplines and of other bran- ches of human knowledge. Nevertheless, it can be demonstrated that proposals as those by Julius von Schlosser and Giulio Carlo Argan enclose reflections and methodological aspects which can help us face the task of understanding and visualizing the mediating role of historians in the culture of sensitivity, and the art modulations that have resulted from the blows of history and that, in turn, have shaped both art and art history into what they are or can be to us today. (shrink)

This paper analyses the arguments for and against what we have called automatic organ procurement model in relation to the organs of the deceased. For this purpose, this work provides empirical evidence to assess the potential impact of this model on donation rates and on public opinion. Specifically, we examine first the reasons supporting this model, with special reference to utilitarian and justice arguments. On the other hand, we analyse both the approaches based on the violation of pre mortem and (...) post mortem interests opposing this theoretical model and the rejection the model would generate in the population. Finally, we point out the aspects that, in our opinion, should be exhaustively regulated if this model were implemented. In particular, we refer to the legal status of the human body, the treatments for end-of-life patients, the incentives for health professionals and the recognition of the right to conscientious objection. (shrink)

En el mundo académico contemporáneo han venido tomando fuerza, desde hace varias décadas, los temas de la interdisciplinariedad y la transdisciplinariedad, como respuesta de un sector de la comunidad científica a los problemas de la especialización y a la desconexión entre las ciencias. Como todo elemento o aspecto de la realidad, este tema requiere de una debida fundamentación filosófica que se encuentra en el pensamiento clásico. En el presente artículo se intenta mostrar la relación entre la tradición de la filosofía (...) perenne y este fundamento, atendiendo, sobre todo, a la importancia de la mirada holística del fenómeno ético y pretendiendo sustentar que el diálogo entre las ciencias sólo es posible rescatando el paradigma metafísico, legado por los griegos a la civilización occidental y defendido por MacIntyre en su libro "Ethics in the Conflicts of Modernity. An Essay on Desire, Practical Reasoning, and Narrative" (University of Cambridge, 2016). (shrink)

Drugs used to provide improvement of cognitive functioning have been shown to be effective in healthy individuals. It is sometimes assumed that the use of these drugs constitutes cheating in an academic context. We examine whether this assumption is ethically sound. Beyond providing the most up-to-date discussion of modafinil use in an academic context, this contribution includes an overview of the safety of modafinil use in greater depth than previous studies addressing the issue of cheating. Secondly, we emphasize two crucial, (...) but hitherto nearly overlooked, nuances to the issues: the potential for modafinil to decrease inequality and disadvantage in academic settings, and the fact that how modafinil is used dramatically impacts its effects on health, coercion, fairness, authenticity and effort. Finally, we explicitly defend the position that there are no qualitatively morally relevant differences between modafinil use and other enhancement modalities; any such differences are in degree,... (shrink)

Vivimos en un mundo poblado de significados. Eso hace que para nosotros estar en el mundo implique un modo muy específico de estar, que es comprensivamente. Nuestra incorporación al mundo no es a un complejo simplemente fáctico de realidades naturales y artificiales, sino a un mundo organizado, y es por eso, en cuanto tal, una incorporación simbólica también, intencional. Todo cuanto nos rodea vehicula estructuras de conocimiento —valores, creencias, normas, aspiraciones comunes…— que hacen que vivir la realidad suponga para cada (...) uno de nosotros vivirla significativamente, vivirla de acuerdo con algún sentido, y no poder vivirla más que así. (shrink)

⦿ In my dissertation I introduce, motivate and take the first steps in the implementation of, the project of naturalising modal metaphysics: the transformation of the field into a chapter of the philosophy of science rather than speculative, autonomous metaphysics. -/- ⦿ In the introduction, I explain the concept of naturalisation that I apply throughout the dissertation, which I argue to be an improvement on Ladyman and Ross' proposal for naturalised metaphysics. I also object to Williamson's proposal that modal metaphysics (...) --- or some view in the area --- is already a quasi-scientific discipline. -/- ⦿ Recently, some philosophers have argued that the notion of metaphysical modality is as ill defined as to be of little theoretical utility. In the second chapter I intend to contribute to such skepticism. First, I observe that each of the proposed marks of the concept, except for factivity, is highly controversial; thus, its logical structure is deeply obscure. With the failure of the "first principles" approach, I examine the paradigmatic intended applications of the concept, and argue that each makes it a device for a very specific and controversial project: a device, therefore, for which a naturalist will find no use for. I conclude that there is no well-defined or theoretically useful notion of objective necessity other than logical or physical necessity, and I suggest that naturalising modal metaphysics can provide more stable methodological foundations. -/- ⦿ In the third chapter I answer a possible objection against the in-principle viability of the project: that the concept of metaphysical modality cannot be understood through the philosophical analysis of any scientific theory, since metaphysical necessity "transcends'' natural necessity, and science only deals with the latter. I argue that the most important arguments for this transcendence thesis fail or face problems that, as of today, remain unsolved. -/- ⦿ Call the idea that science doesn't need modality, "demodalism''. Demodalism is a first step in a naturalistic argument for modal antirealism. In the fourth chapter I examine six versions of demodalism to explain why a family of formalisms, that I call "spaces of possibility'', are (i) used in a quasi-ubiquitous way in mathematised sciences (I provide examples from theoretical computer science to microeconomics), (ii) scientifically interpreted in modal terms, and (iii) used for at least six important tasks: (1) defining laws and theories; (2) defining important concepts from different sciences (I give several examples); (3) making essential classifications; (4) providing different types of explanations; (5) providing the connection between theory and statistics, and (6) understanding the transition between a theory and its successor (as is the case with quantisation). -/- ⦿ In fifth chapter I propose and defend a naturalised modal ontology. This is a realism about modal structure: my realism about constraints. The modal structure of a system are the relationships between its possible states and between its possible states and those of other systems. It is given by the plurality of restrictions to which said system is subject. A constraint is a factor that explains the impossibility of a class of states; I explain this concept further. First, I defend my point of view by rejecting some of its main rivals: constructive empiricism, Humean conventionalism, and wave function realism, as they fail to make sense of quantum chaos. This is because the field requires the notion of objective modal structure, and the mentioned views have trouble explaining the modal facts of quantum dynamics. Then, I argue that constraint realism supersedes these views in the context of Bohm's standard theory and mechanics, and underpins the study of quantum chaos. Finally, I consider and reject two possible problems for my point of view. -/- ⦿ A central concern of modal metaphysicians has been to understand the logical system that best characterises necessity. In the sixth chapter I intend to recover the logical project applied to my naturalistic modal metaphysics. Scientists and philosophers of science accept different degrees of physical necessity, ranging from purely mathematically necessary facts that restrict physical behaviour, to kinetic principles, to particular dynamical constraints. I argue that this motivates a multimodal approach to modal logic, and that the time dependence of dynamics motivates a logic of historical necessity. I propose multimodal propositional (classical) logics for Bohmian mechanics and the Everettian theory of many divergent worlds, and I close with a criticism of Williamson's approach to the logic of state spaces of dynamic systems. (shrink)

El Foro Global de Bioética en Investigación (GFBR por sus siglas en inglés) se reunió el 3 y 4 de noviembre en Buenos Aires, Argentina, con el objetivo de discutir la ética de la investigación con mujeres embarazadas. El GFBR es una plataforma mundial que congrega a actores clave con el objetivo de promover la investigación realizada de manera ética, fortalecer la ética de la investigación en salud, particularmente en países de ingresos bajos y medios, y promover colaboración entre países (...) del norte y del sur.a Los participantes en el GFBR provenientes de Latinoamérica incluyeron a eticistas, investigadores, miembros de comités de ética y representantes de autoridades sanitarias provenientes de Argentina, Brasil, Chile, Colombia, Ecuador, El Salvador, Guatemala, Honduras, Panamá, Perú, Nicaragua y la República Dominicana. Una legítima preocupación por la protección de las mujeres embarazadas y sus embriones o fetos ha llevado a la mayoría de los países de la Región de las Américas a limitar la realización de estudios con mujeres embarazadas exclusivamente a aquellos estudios específicos sobre el embarazo, y a requerir la exclusión sistemática de las mujeres embarazadas o de las mujeres que quedan embarazadas en el curso del estudio. Ciertamente, a lo largo de la historia de la ética de la investigación, se ha creído erróneamente que proteger a una población es sinónimo de excluirla de los estudios. Se sabe ahora que proceder así implica exponer a riesgos mucho mayores a la población que se busca proteger. El embarazo implica cambios fisiológicos sustantivos e impacta profundamente la manera como el cuerpo metaboliza los medicamentos. Sin embargo, por evitar hacer investigación con mujeres embarazadas, no se ha producido la evidencia científica necesaria para tomar decisiones sobre tratamientos e intervenciones preventivas con dosis eficaces y seguras para ellas y sus embriones o fetos. A manera de ilustración, en el 2001 había en los Estados Unidos apenas más de una docena de medicamentos aprobados para uso en el embarazo (1) y en el 2011 la Food and Drug Administration (FDA) aprobó por primera vez en 15 años un medicamento para su uso en el embarazo (2). Como consecuencia de no haber producido la evidencia necesaria, se pone en riesgo la salud de las mujeres embarazadas cada vez que se les da atención médica. Las mujeres embarazadas se enferman y las mujeres enfermas se embarazan, y no se sabe si los medicamentos que se les da son eficaces o siquiera seguros para ellas y sus embriones o fetos. (shrink)

Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE) for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymptotic results and cannot guarantee a good performance in the presence of low frequency genotypes. Since the parameter space dimension increases at a quadratic rate on (...) the number of alleles, some authors suggest applying sequential methods, where the multiallelic case is reformulated as a sequence of “biallelic” tests. However, in this approach it is not obvious how to assess the general evidence of the original hypothesis; nor is it clear how to establish the significance level for its acceptance/rejection. In this work, we introduce a straightforward method for the multiallelic HWE test, which overcomes the aforementioned issues of sequential methods. The core theory for the proposed method is given by the Full Bayesian Significance Test (FBST), an intuitive Bayesian approach which does not assign positive probabilities to zero measure sets when testing sharp hypotheses. We compare FBST performance to Chi-square, Likelihood-ratio and Markov chain tests, in three numerical experiments. The results suggest that FBST is a robust and high performance method for the HWE test, even in the presence of several alleles and small sample sizes. (shrink)

t Intentional sampling methods are non-randomized procedures that select a group of individuals for a sample with the purpose of meeting specific prescribed criteria. In this paper we extend previous works related to intentional sampling, and address the problem of sequential allocation for clinical trials with few patients. Roughly speaking, patients are enrolled sequentially, according to the order in which they start the treatment at the clinic or hospital. The allocation problem consists in assigning each new patient to one, and (...) only one, of the alternative treatment arms. The main requisite is that the profiles in the alternative arms remain similar with respect to some relevant patients’ attributes (age, gender, disease, symptom severity and others). We perform numerical experiments based on a real case study and discuss how to conveniently set up perturbation parameters, in order to yield a suitable balance between optimality – the similarity among the relative frequencies of patients in the several categories for both arms, and decoupling – the absence of a tendency to allocate each pair of patients consistently to the same arm. (shrink)

En medio de tanta charla irresponsable que inunda los diversos medios de comunicación y las tribunas gubernamentales sobre la educación, en el que se figura la viabilidad del país desde lo económico y no desde lo civilizado, recordé las “uvas verdes”, esa referencia que Gombrich utilizó en una de sus tantas conferencias sobre las humanidades. La fábula de Esopo da qué pensar sobre la valoración de las humanidades en la malla de las instituciones de educación superior. Los juicios despreciables que (...) aparecen bajo la forma de la innovación, a partir de indicadores y criterios de examinabilidad que promueve el gobierno, los ministerios y Colciencias, son solo una muestra de cómo esa charla fácil pretende circunscribir a las humanidades en el nuevo paraíso medible del ámbito académico. (shrink)

The Full Bayesian Significance Test, FBST, is extensively reviewed. Its test statistic, a genuine Bayesian measure of evidence, is discussed in detail. Its behavior in some problems of statistical inference like testing for independence in contingency tables is discussed.

Tendo em vista que a lei de ser em relação ao sujeito cognoscente consiste em ser-consciente, a consciência, segundo Jean-Paul Sartre, sobrepõe-se ao status de modo particular de conhecimento enquanto sentido interno ou conhecimento como conhecimento de si, constituindo a dimensão de ser transfenomenal. Dessa forma, baseado no princípio fenomenológico-ontológico-existencial, o Prof. Luiz Carlos Mariano Da Rosa se detém na relação entre o fenômeno de ser e o ser do fenômeno e na irredutibilidade do ser do fenômeno ao fenômeno (...) do ser, assinalando o processo que sobrepõe o ser do fenômeno à condição fenomênica e converge para a consciência enquanto ser cognoscente enquanto é em um movimento que escapa ao enquanto é conhecido, transpondo as fronteiras da preeminência do conhecimento. Se a consciência emerge como consciência de alguma coisa em um processo cujo ser implica um ser que encerra a si como não consciente e transfenomenal, o que se impõe, segundo Sartre, não é senão a consciência como um ser que encerra a questão do seu ser enquanto ser que implica outro ser que não si mesmo. Assim, detendo-se no acontecimento da aparição do existente humano em relação ao ser enquanto descoberta de um mundo e a negação como momento essencial e primordial, o artigo assinala o motivo pelo qual o existente humano em seu ser implica a possibilidade de aparição do nada em um processo que encerra a liberdade como condição para a nadificação do nada. (shrink)

We present a module based criterion, i.e. a sufficient condition based on the absolute value of the matrix coefficients, for the convergence of Gauss–Seidel method (GSM) for a square system of linear algebraic equations, the Generalized Line Criterion (GLC). We prove GLC to be the “most general” module based criterion and derive, as GLC corollaries, some previously know and also some new criteria for GSM convergence. Although far more general than the previously known results, the proof of GLC is simpler. (...) The results used here are related to recent research in stability of dynamical systems and control of manufacturing systems. (shrink)

The data analyzed in this paper are part of the results described in Bueno et al. (2000). Three cytogenetics endpoints were analyzed in three populations of a species of wild rodent – Akodon montensis – living in an industrial, an agricultural, and a preservation area at the Itajaí Valley, State of Santa Catarina, Brazil. The polychromatic/normochromatic ratio, the mitotic index, and the frequency of micronucleated polychromatic erythrocites were used in an attempt to establish a genotoxic profile of each area. It (...) was assumed that the three populations were in the same conditions with respect to the influence of confounding factors such as animal age, health, nutrition status, presence of pathogens, and intra- and inter-populational genetic variability. Therefore, any differences found in the endpoints analyzed could be attributed to the external agents present in each area. The statistical models used in this paper are mixtures of negative-binomials and Poisson variables. The Poisson variables are used as approximations of binomials for rare events. The mixing distributions are beta densities. The statistical analyzes are under the bayesian perspective, as opposed to the frequentist ones often considered in the literature, as for instance in Bueno et al. (2000). (shrink)

Gene clustering is a useful exploratory technique to group together genes with similar expression levels under distinct cell cycle phases or distinct conditions. It helps the biologist to identify potentially meaningful relationships between genes. In this study, we propose a clustering method based on multivariate normal mixture models, where the number of clusters is predicted via sequential hypothesis tests: at each step, the method considers a mixture model of m components (m = 2 in the first step) and tests if (...) in fact it should be m - 1. If the hypothesis is rejected, m is increased and a new test is carried out. The method continues (increasing m) until the hypothesis is accepted. The theoretical core of the method is the full Bayesian significance test, an intuitive Bayesian approach, which needs no model complexity penalization nor positive probabilities for sharp hypotheses. Numerical experiments were based on a cDNA microarray dataset consisting of expression levels of 205 genes belonging to four functional categories, for 10 distinct strains of Saccharomyces cerevisiae. To analyze the method’s sensitivity to data dimension, we performed principal components analysis on the original dataset and predicted the number of classes using 2 to 10 principal components. Compared to Mclust (model-based clustering), our method shows more consistent results. (shrink)